Dynein-mediated vesicle transport controls intracellular Salmonella replication.

  title={Dynein-mediated vesicle transport controls intracellular Salmonella replication.},
  author={Marije Marsman and Ingrid Jordens and Coen Kuijl and Lennert Janssen and Jacques Neefjes},
  journal={Molecular biology of the cell},
  volume={15 6},
Salmonella typhimurium survives and replicates intracellular in a membrane-bound compartment, the Salmonella-containing vacuole (SCV). In HeLa cells, the SCV matures through interactions with the endocytic pathway, but Salmonella avoids fusion with mature lysosomes. The exact mechanism of the inhibition of phagolysosomal fusion is not understood. Rab GTPases control several proteins involved in membrane fusion and vesicular transport. The small GTPase Rab7 regulates the transport of and fusion… CONTINUE READING