Dynein light chain 1 peptide inhibits human immunodeficiency virus infection in eukaryotic cells.

@article{Fontenot2007DyneinLC,
  title={Dynein light chain 1 peptide inhibits human immunodeficiency virus infection in eukaryotic cells.},
  author={Danielle Renee Fontenot and Petra L C den Hollander and Eric Michael Vela and Robert J. Newman and Jagannadha K. Sastry and Rakesh Kumar},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={363 4},
  pages={901-7}
}
Human immunodeficiency virus (HIV) uses kinases such as Pak1 and macropinocytosis for a productive infection. Recently dynein light chain 1 (DLC1), a component of the dynein motor, was identified as a Pak1 substrate and interacted with the C-terminal region of DLC1 (aa 61-89). The dynein motor is implicated in retrograde transport, also of HIV, to the… CONTINUE READING