Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation

@inproceedings{Dunsch2012DyneinLC,
  title={Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation},
  author={Anja K. Dunsch and Dean Hammond and Jennifer Anne Lloyd and Lothar Schermelleh and Ulrike Gruneberg and Francis A Barr},
  booktitle={The Journal of cell biology},
  year={2012}
}
The cytoplasmic dynein motor generates pulling forces to center and orient the mitotic spindle within the cell. During this positioning process, dynein oscillates from one pole of the cell cortex to the other but only accumulates at the pole farthest from the spindle. Here, we show that dynein light chain 1 (DYNLL1) is required for this asymmetric cortical localization of dynein and has a specific function defining spindle orientation. DYNLL1 interacted with a spindle-microtubule-associated… CONTINUE READING
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