Dynein drives nuclear rotation during forward progression of motile fibroblasts.

@article{Levy2008DyneinDN,
  title={Dynein drives nuclear rotation during forward progression of motile fibroblasts.},
  author={Jennifer R. Levy and Erika L. F. Holzbaur},
  journal={Journal of cell science},
  year={2008},
  volume={121 Pt 19},
  pages={3187-95}
}
During directed cell migration, the movement of the nucleus is coupled to the forward progression of the cell. The microtubule motor cytoplasmic dynein is required for both cell polarization and cell motility. Here, we investigate the mechanism by which dynein contributes to directed migration. Knockdown of dynein slows protrusion of the leading edge and causes defects in nuclear movements. The velocity of nuclear migration was decreased in dynein knockdown cells, and nuclei were mislocalized… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 52 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

polarity in migrating astrocytes through PKCzeta

  • S. Even-Ram, A. D. Doyle, M. A. Conti, K. Matsumoto, R. S. Adelstein, K. M. Yamada
  • 2007
1 Excerpt

Similar Papers

Loading similar papers…