Dynein-driven mitotic spindle positioning restricted to anaphase by She1p inhibition of dynactin recruitment.

@article{Woodruff2009DyneindrivenMS,
  title={Dynein-driven mitotic spindle positioning restricted to anaphase by She1p inhibition of dynactin recruitment.},
  author={Jeffrey B Woodruff and David G Drubin and Georjana Barnes},
  journal={Molecular biology of the cell},
  year={2009},
  volume={20 13},
  pages={
          3003-11
        }
}
Dynein is a minus-end-directed microtubule motor important for mitotic spindle positioning. In budding yeast, dynein activity is restricted to anaphase when the nucleus enters the bud neck, yet the nature of the underlying regulatory mechanism is not known. Here, the microtubule-associated protein She1p is identified as a novel regulator of dynein activity. In she1 Delta cells, dynein is activated throughout the cell cycle, resulting in aberrant spindle movements that misposition the spindle… CONTINUE READING
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