Dynein Tethers and Stabilizes Dynamic Microtubule Plus Ends

  title={Dynein Tethers and Stabilizes Dynamic Microtubule Plus Ends},
  author={Adam G. Hendricks and Jacob E. Lazarus and Eran Perlson and Melissa K Gardner and David J. Odde and Yale E. Goldman and Erika L. F. Holzbaur},
  journal={Current Biology},
Microtubules undergo alternating periods of growth and shortening, known as dynamic instability. These dynamics allow microtubule plus ends to explore cellular space. The "search and capture" model posits that selective anchoring of microtubule plus ends at the cell cortex may contribute to cell polarization, spindle orientation, or targeted trafficking to specific cellular domains. Whereas cytoplasmic dynein is primarily known as a minus-end-directed microtubule motor for organelle transport… CONTINUE READING


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