Dynein Associates with oskar mRNPs and Is Required For Their Efficient Net Plus-End Localization in Drosophila Oocytes

@inproceedings{Sanghavi2013DyneinAW,
  title={Dynein Associates with oskar mRNPs and Is Required For Their Efficient Net Plus-End Localization in Drosophila Oocytes},
  author={Paulomi B. Sanghavi and Shobha Laxani and Xuan Li and Simon L Bullock and Graydon B Gonsalvez},
  booktitle={PloS one},
  year={2013}
}
In order for eukaryotic cells to function properly, they must establish polarity. The Drosophila oocyte uses mRNA localization to establish polarity and hence provides a genetically tractable model in which to study this process. The spatial restriction of oskar mRNA and its subsequent protein product is necessary for embryonic patterning. The localization of oskar mRNA requires microtubules and microtubule-based motor proteins. Null mutants in Kinesin heavy chain (Khc), the motor subunit of… CONTINUE READING
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