Dynamin2 downregulation delays EGFR endocytic trafficking and promotes EGFR signaling and invasion in hepatocellular carcinoma.

@article{Gong2015Dynamin2DD,
  title={Dynamin2 downregulation delays EGFR endocytic trafficking and promotes EGFR signaling and invasion in hepatocellular carcinoma.},
  author={Chaojie Gong and Jubo Zhang and Lan Zhang and Yingcong Wang and Hui Ma and Weiwei Wu and Jiefeng Cui and Yingying Wang and Zheng-gang Ren},
  journal={American journal of cancer research},
  year={2015},
  volume={5 2},
  pages={702-13}
}
Dysregulation of endocytosis was viewed as an emerging feature of cancer development and progression. A large GTPase dynamin2 plays a significant role in receptor tyrosine kinases (RTKs) endocytosis. The study was designed to investigate its roles in hepatocellular carcinoma (HCC) metastasis and its underlying mechanism. Dynamin2 expression in cancer tissues from HCC patients was assessed by immunohistochemistry and its prognostic significance for the patients was conducted using univariate and… CONTINUE READING

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