• Biology, Medicine
• Published in Nature 1995
• DOI:10.1038/374190a0

Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding

@article{Hinshaw1995DynaminSI,
  title={Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding},
  author={Jenny E. Hinshaw and Sandra L Schmid},
  journal={Nature},
  year={1995},
  volume={374},
  pages={190-192}
}

• Jenny E. Hinshaw, Sandra L Schmid

DYNAMIN, a 100K member of the GTPase superfamily1, is the mammalian homologue of the Drosophila shibire gene product2,3. Mutations in shibire cause a defect in endocytosis leading to accumulation of coated pits and deep imaginations at the plasma membrane of all tissues examined4,5. Similarly, invaginated coated pits accumulate in mammalian cells overexpressing dominant-negative mutants of dynamin, establishing that dynamin is required for the formation of 'constricted' coated pits and for… CONTINUE READING

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