Dynamin is required for the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase.

@article{Kranenburg1999DynaminIR,
  title={Dynamin is required for the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase.},
  author={Onno W. Kranenburg and Ingrid Verlaan and Wouter H Moolenaar},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 50},
  pages={35301-4}
}
Internalization of activated receptors from the plasma membrane has been implicated in the activation of mitogen-activated protein (MAP) kinase. However, the mechanism whereby membrane trafficking may regulate mitogenic signaling remains unclear. Here we report that dominant-negative dynamin (K44A), an inhibitor of endocytic vesicle formation, abrogates MAP kinase activation in response to epidermal growth factor, lysophosphatidic acid, and protein kinase C-activating phorbol ester. In contrast… CONTINUE READING

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