Dynamin inhibits phosphatidylinositol 3-kinase in hematopoietic cells.

  title={Dynamin inhibits phosphatidylinositol 3-kinase in hematopoietic cells.},
  author={Dee Harrison-Findik and Suniti Misra and Suresh Kumar Jain and Marilyn L Keeler and Kimerly A. Powell and Chandra S. Malladi and Lyuba Varticovski and Phillip J Robinson},
  journal={Biochimica et biophysica acta},
  volume={1538 1},
Phosphatidylinositol 3-kinase (PI 3-kinase) plays a role in late stages of endocytosis as well as in cellular proliferation and transformation. The SH3 domain of its regulatory p85 subunit stimulates the GTPase activity of dynamin in vitro. Dynamin is a GTPase enzyme required for endocytosis of activated growth factor receptors. An interaction between these… CONTINUE READING