Dynamin impacts homology-directed repair and breast cancer response to chemotherapy.

@article{Chernikova2018DynaminIH,
  title={Dynamin impacts homology-directed repair and breast cancer response to chemotherapy.},
  author={Sophia B. Chernikova and Rochelle B. Nguyen and Jessica T. Truong and Stephano Span{\'o} Mello and Jason H. Stafford and Michael P. Hay and Andrew Olson and David E. Solow-Cordero and Douglas J. Wood and Solomon Henry and Rie von Eyben and Lei Deng and Melanie Hayden Gephart and Asaithamby Aroumougame and Claudia Anette Elisabeth Wiese and John C. Game and Bal{\'a}zs Győrffy and Jared M Brown},
  journal={The Journal of clinical investigation},
  year={2018},
  volume={128 12},
  pages={
          5307-5321
        }
}
After the initial responsiveness of triple-negative breast cancers (TNBCs) to chemotherapy, they often recur as chemotherapy-resistant tumors, and this has been associated with upregulated homology-directed repair (HDR). Thus, inhibitors of HDR could be a useful adjunct to chemotherapy treatment of these cancers. We performed a high-throughput chemical screen for inhibitors of HDR from which we obtained a number of hits that disrupted microtubule dynamics. We postulated that high levels of the… CONTINUE READING
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