Dynamin and rab5 regulate GRK2-dependent internalization of dopamine D2 receptors.

  title={Dynamin and rab5 regulate GRK2-dependent internalization of dopamine D2 receptors.},
  author={Koichi Iwata and Katsuhiko Ito and A Fukuzaki and Koichiro Inaki and Tatsuya Haga},
  journal={European journal of biochemistry},
  volume={263 2},
Dopamine D2 receptors (D2Rs; short form, which is one of the alternative splicing variants) expressed in COS-7 cells are internalized in an agonist-dependent manner only when G protein-coupled receptor kinase 2 (GRK2) is coexpressed [Ito, K., Haga, T., Lameh, J. & Sadée, W., (1999) Eur. J. Biochem. 260, 112-119]. We have examined the effects of coexpression of dynamin, a small molecular mass GTP-binding protein, rab5A, and their mutants on the internalization of D2Rs in the presence of both… CONTINUE READING


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