Dynamin I plays dual roles in the activity-dependent shift in exocytic mode in mouse adrenal chromaffin cells.

@article{Fulop2008DynaminIP,
  title={Dynamin I plays dual roles in the activity-dependent shift in exocytic mode in mouse adrenal chromaffin cells.},
  author={Tiberiu G. Fulop and Bryan William Doreian and Corey B. Smith},
  journal={Archives of biochemistry and biophysics},
  year={2008},
  volume={477 1},
  pages={146-54}
}
Under low stimulation, adrenal chromaffin cells release freely soluble catecholamines through a restricted granule fusion pore while retaining the large neuropeptide-containing proteinacious granule core. Elevated activity causes dilation of the pore and release of all granule contents. Thus, physiological differential transmitter release is achieved through regulation of fusion pore dilation. We examined the mechanism for pore dilation utilizing a combined approach of peptide transfection… CONTINUE READING

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