Dynamin-2 Stabilizes the HIV-1 Fusion Pore with a Low Oligomeric State

@inproceedings{Jones2017Dynamin2ST,
  title={Dynamin-2 Stabilizes the HIV-1 Fusion Pore with a Low Oligomeric State},
  author={Daniel M. Jones and Luis A. J. Alvarez and Rory Nolan and Margarita Ferriz and Raquel Sainz Urruela and X{\`e}nia Massana-Mu{\~n}oz and Hila Novak-Kotzer and Michael L. Dustin and Sergi Padilla-Parra},
  booktitle={Cell reports},
  year={2017}
}
One of the key research areas surrounding HIV-1 concerns the regulation of the fusion event that occurs between the virus particle and the host cell during entry. Even if it is universally accepted that the large GTPase dynamin-2 is important during HIV-1 entry, its exact role during the first steps of HIV-1 infection is not well characterized. Here, we have utilized a multidisciplinary approach to study the DNM2 role during fusion of HIV-1 in primary resting CD4 T and TZM-bl cells. We have… CONTINUE READING
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