Dynamin: switch or pinchase?

  title={Dynamin: switch or pinchase?},
  author={Heather M. Thompson and Mark A. McNiven},
  journal={Current Biology},
What is it? Dynamin is a protein that is essential for severing nascent endocytic pits from the plasma membrane to form vesicles. According to whom you speak, dynamin is either a molecular 'switch', or a pinchase-like mechanoenzyme. What is a switch and what is a mechanoenzyme? Small GTPases of the Ras superfamily are often thought of as switches that control cellular events. These enzymes, when GTP-bound, are in an active state. Upon GTP hydrolysis, they become inactive and thus 'off'. Hence… CONTINUE READING


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