Dynamin, a membrane-remodelling GTPase

  title={Dynamin, a membrane-remodelling GTPase},
  author={Shawn M Ferguson and Pietro De Camilli},
  journal={Nature Reviews Molecular Cell Biology},
Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in membrane remodelling, has a critical role in endocytic membrane fission events. The use of complementary approaches, including live-cell imaging, cell-free studies, X-ray crystallography and genetic studies in mice, has greatly advanced our understanding of the mechanisms by which dynamin acts, its essential roles in cell physiology and the specific function of different dynamin isoforms. In addition, several… CONTINUE READING
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