Dynamics of unfolded polypeptide chains as model for the earliest steps in protein folding.

@article{Krieger2003DynamicsOU,
  title={Dynamics of unfolded polypeptide chains as model for the earliest steps in protein folding.},
  author={Florian Krieger and Beat Fierz and Oliver Bieri and Mario Drewello and Thomas Kiefhaber},
  journal={Journal of molecular biology},
  year={2003},
  volume={332 1},
  pages={265-74}
}
The rate of formation of intramolecular interactions in unfolded proteins determines how fast conformational space can be explored during folding. Characterization of the dynamics of unfolded proteins is therefore essential for the understanding of the earliest steps in protein folding. We used triplet-triplet energy transfer to measure formation of intrachain contacts in different unfolded polypeptide chains. The time constants (1/k) for contact formation over short distances are almost… CONTINUE READING

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