Dynamics of tyrosine hydroxylase promoter activity during midbrain dopaminergic neuron development.

@article{Matsushita2002DynamicsOT,
  title={Dynamics of tyrosine hydroxylase promoter activity during midbrain dopaminergic neuron development.},
  author={Natsuki Matsushita and Hideki Okada and Yasunobu Yasoshima and Kazuaki Takahashi and Kazutoshi Kiuchi and Kazuto Kobayashi},
  journal={Journal of neurochemistry},
  year={2002},
  volume={82 2},
  pages={295-304}
}
Dopamine (DA)-producing neurons in the ventral midbrain are generated from a specified neuronal lineage and form selective axonal pathways that mediate multiple CNS functions. Expression of the gene encoding tyrosine hydroxylase (TH), which is a key enzyme of catecholamine biosynthesis, is regulated during the development of midbrain DA neurons. In the present study, we report the developmental regulation and cell type specificity of TH gene promoter in the ventral midbrain by using a green… CONTINUE READING

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