Dynamics of the immune reaction to pancreatic cancer from inception to invasion.

@article{Clark2007DynamicsOT,
  title={Dynamics of the immune reaction to pancreatic cancer from inception to invasion.},
  author={Carolyn E. Clark and Sunil Hingorani and Rosemarie Mick and Chelsea Combs and David A Tuveson and Robert H. Vonderheide},
  journal={Cancer research},
  year={2007},
  volume={67 19},
  pages={9518-27}
}
The dynamics of cancer immunosurveillance remain incompletely understood, hampering efforts to develop immunotherapy of cancer. We evaluated the evolving in vivo immune response to a spontaneous tumor in a genetically defined mouse model of pancreatic ductal adenocarcinoma from the inception of preinvasive disease to invasive cancer. We observed a prominent leukocytic infiltration even around the lowest grade preinvasive lesions, but immunosuppressive cells, including tumor-associated… CONTINUE READING
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