Dynamics of the global tyrosine phosphorylation during capacitation and acquisition of the ability to fuse with oocytes in human spermatozoa.

@article{Barbonetti2008DynamicsOT,
  title={Dynamics of the global tyrosine phosphorylation during capacitation and acquisition of the ability to fuse with oocytes in human spermatozoa.},
  author={Arcangelo Barbonetti and Maria Rosaria Caterina Vassallo and Benedetta Cinque and C Antonangelo and Francesco Sciarretta and Riccardo Santucci and Anatolia d'Angeli and Sandro Francavilla and Felice Francavilla},
  journal={Biology of reproduction},
  year={2008},
  volume={79 4},
  pages={649-56}
}
Phosphorylation of tyrosine residues in cellular proteins represents a major event during sperm capacitaton, but its relationship with the acquisition of sperm-fertilizing ability is still unclear. In this study we explored the relationship between the kinetics of the global tyrosine phosphorylation, monitored with a flow cytometric assay, and the acquisition of the human sperm ability to fuse with oocytes, evaluated with the progesterone-enhanced hamster egg penetration test. Sperm tyrosine… CONTINUE READING

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