Dynamics of the cell and its extracellular matrix - a simple mathematical approach

@article{Saha2003DynamicsOT,
  title={Dynamics of the cell and its extracellular matrix - a simple mathematical approach},
  author={A. K. Saha and J. Mazumdar},
  journal={IEEE Transactions on NanoBioscience},
  year={2003},
  volume={2},
  pages={89-93}
}
The extracellular matrix (ECM) is produced by the cells and secreted into the surrounding medium, and consists of a complex mixture of structural and functional proteins. It has been recently observed that the ECM can influence the behavior of cell growth in vitro quite remarkably. A simple mathematical model has been constructed based on negative feedback control mechanisms to represent the dynamics of ECM deposition and cellular differentiation. The model analysis shows a strong relationship… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 23 references

and E

  • M. D. Buschmann, Y. A. Gluzband, A. J. Grodzinsky, J. H. Kimura
  • B. Hunziker, “Chondrocytes in agarose culture…
  • 1992
Highly Influential
5 Excerpts

Interactionof chondrocytes, extracellular matrix and growth factors: Relevance for articular cartilage tissue engineering,

  • P. M. van der Kraan, P. Buma, T. van Kuppevelt, W. B. van den Berg
  • Osteoarthritis Cartilage,
  • 2002
2 Excerpts

and A

  • J. Kisiday, M. Jin, H. H. Hung, B. Kurz, S. Zhang
  • J. Grodzinsky, “Self-assembling peptide hydrogel…
  • 2002
1 Excerpt

The effects of cross - linking of collagen - glycosaminoglycan scaffolds on compressive stiffness , chondrocyte - mediated contraction , proliferation and biosynthesis

  • F. Ruggier Mallein-Gerin, T. M. Quinn, F. Brad, A. J. Grodzinsky, B. R. Olsen, M. van der Rest
  • Biomaterials
  • 2001

and G

  • B. Obradovic, J. H. Meldon, L. E. Freed
  • Vunjak-Novakovic, “Glycosaminoglycan deposition…
  • 2000

and J

  • P. M. Ragan, V. I. Chin, +4 authors A. J. Grodzinsky
  • D. Sandy, “Chondrocyte extracellular matrix…
  • 2000
3 Excerpts

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