Dynamics of the CapG actin-binding protein in the cell nucleus studied by FRAP and FCS

@article{Renz2008DynamicsOT,
  title={Dynamics of the CapG actin-binding protein in the cell nucleus studied by FRAP and FCS},
  author={Malte Renz and J{\"o}rg Langowski},
  journal={Chromosome Research},
  year={2008},
  volume={16},
  pages={427-437}
}
FRAP (fluorescence recovery after photobleaching) and FCS (fluorescence correlation spectroscopy) are spectroscopic methods for monitoring the dynamic distribution of proteins inside the nucleus of living cells. As an example we report our studies on the intracellular mobility of the actin-binding protein CapG in live breast cancer cells. This Gelsolin-related protein is a putative oncogene. It appears to be overexpressed especially in metastasizing breast cancer. Furthermore, the CapG protein… CONTINUE READING
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