Dynamics of skeletal pattern formation in developing chick limb.

@article{Newman1979DynamicsOS,
  title={Dynamics of skeletal pattern formation in developing chick limb.},
  author={Stuart A. Newman and Harry L. Frisch},
  journal={Science},
  year={1979},
  volume={205 4407},
  pages={662-8}
}
During development of the embryonic chick limb the skeletal pattern is laid out as cartilaginous primordia, which emerge in a proximodistal sequence over a period of 4 days. The differentiation of cartilage is preceded by changes in cellular contacts at specific locations in the precartilage mesenchyme. Under realistic assumptions, the biosynthesis and diffusion through the extracellular matrix of a cell surface protein, such as fibronectin, will lead to spatial patterns of this molecule that… CONTINUE READING

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