Dynamics of signal transduction after aggregation of cell-surface receptors: studies on the type I receptor for IgE.

@article{Kent1994DynamicsOS,
  title={Dynamics of signal transduction after aggregation of cell-surface receptors: studies on the type I receptor for IgE.},
  author={Ute M. Kent and Shi Yun Mao and Carla Wofsy and Byron Goldstein and Suzanne Ross and Henry Metzger},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 8},
  pages={3087-91}
}
Many ligands stimulate cellular responses by aggregating the cell-surface receptors to which they are bound. We investigated several mechanistic questions related to aggregation of receptors by using the high-affinity receptor for IgE (Fc epsilon RI) on mast cells as a model system. We briefly exposed cells to covalently cross-linked oligomers of IgE and then added excess monomeric IgE to prevent further aggregation. Early events were examined by monitoring the phosphorylation of protein… CONTINUE READING
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