Dynamics of ribosomes in mRNA translation under steady- and nonsteady-state conditions.

@article{SzavitsNossan2020DynamicsOR,
  title={Dynamics of ribosomes in mRNA translation under steady- and nonsteady-state conditions.},
  author={Juraj Szavits-Nossan and Martin R. Evans},
  journal={Physical review. E},
  year={2020},
  volume={101 6-1},
  pages={
          062404
        }
}
Recent advances in DNA sequencing and fluorescence imaging have made it possible to monitor the dynamics of ribosomes actively engaged in messenger RNA (mRNA) translation. Here, we model these experiments within the inhomogeneous totally asymmetric simple exclusion process (TASEP) using realistic kinetic parameters. In particular, we present analytic expressions to describe the following three cases: (a) translation of a newly transcribed mRNA, (b) translation in the steady state and… 
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