Dynamics of proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis (CIA).

@article{MarinovaMutafchieva1997DynamicsOP,
  title={Dynamics of proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis (CIA).},
  author={Lilla Marinova-Mutafchieva and R O Williams and Lesley J Mason and C Mauri and Marc Feldmann and Ravinder N. Maini},
  journal={Clinical and experimental immunology},
  year={1997},
  volume={107 3},
  pages={507-12}
}
This report contains a description of the cellular localization and kinetics of proinflammatory cytokine expression in murine CIA, a model for rheumatoid arthritis. Tissue cryostat sections of undecalcified paws from type II collagen-immunized DBA/1 mice, taken 1-10 days after the onset of clinical arthritis, were examined for the presence of tumour necrosis factor-alpha (TNF-alpha), IL-1beta and IL-6 using an indirect immunoperoxidase technique. In parallel, interferon-gamma (IFN-gamma… CONTINUE READING

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