Dynamics of photoinduced endosomal release of polyplexes.

Abstract

Endosomal escape is a well-known bottleneck for successful delivery of macromolecular drugs and genes. Photochemical disruption of endosomal membranes is an approach to overcome this bottleneck. In this study, we used the photosensitizer disulphonated meso-tetraphenylporphine with sulfonate groups on adjacent phenyl rings (TPPS(2a)) to investigate… (More)
DOI: 10.1016/j.jconrel.2008.06.001

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