Dynamics of nuclear receptor movement and transcription.

  title={Dynamics of nuclear receptor movement and transcription.},
  author={Gordon L. Hager and Akhilesh K. Nagaich and Thomas A. Johnson and Dawn A Walker and S Rose John},
  journal={Biochimica et biophysica acta},
  volume={1677 1-3},
Following a hormone signal, steroid/nuclear receptors bind regulatory elements in chromatin and initiate the recruitment of a variety of multi-protein complexes to promoter sequences. These complexes ultimately lead to the recruitment of general transcription factors and the initiation of transcription. Traditional models suggest that these factors remain statically bound to each other and to chromatin until other signals are received to reduce transcription. Recent findings demonstrate that… CONTINUE READING


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