Dynamics of nuclear localization sites for COX-2 in vascular endothelial cells.

@article{Parfenova2001DynamicsON,
  title={Dynamics of nuclear localization sites for COX-2 in vascular endothelial cells.},
  author={Helena Parfenova and Vladimir N. Parfenov and Boris V Shlopov and Vladimir Levine and Sheryl A. Falkos and Massroor Pourcyrous and Charles W. Leffler},
  journal={American journal of physiology. Cell physiology},
  year={2001},
  volume={281 1},
  pages={C166-78}
}
We investigated the relationships among expression, activity, and spatial organization of cyclooxygenase (COX-1 and COX-2) in endothelial cells from porcine and human cerebral microvessels and from human umbilical vein. In quiescent cells, COX-1 was detected in the perinuclear zone and the cytoplasm, while COX-2 was mainly a nuclear resident possibly… CONTINUE READING