Dynamics of microvascular remodelling during tumor growth in bone.

  title={Dynamics of microvascular remodelling during tumor growth in bone.},
  author={Ina Fuhrhop and Malte Schroeder and Svanheidur Loa Rafnsd{\'o}ttir and Lennart Viezens and Wolfgang R{\"u}ther and Nils Hansen-Algenstaedt and Christian Schaefer},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  volume={28 1},
Microcirculatory properties of tumors have been shown to play a pivotal role in tumor progression and inefficacy of therapies. Although the influence of the microenvironment on angiogenesis has been intensively investigated in soft tissue tumors, little is known about the microvascular properties in bone metastasis. To determine the impact of the bone microenvironment on tumor growth and microcirculation we performed intravital microscopy using the "femur window" after implantation of red… CONTINUE READING