Dynamics of memory B-cell populations in blood, lymph nodes, and bone marrow during antiretroviral therapy and envelope boosting in simian immunodeficiency virus SIVmac251-infected rhesus macaques.

@article{Demberg2012DynamicsOM,
  title={Dynamics of memory B-cell populations in blood, lymph nodes, and bone marrow during antiretroviral therapy and envelope boosting in simian immunodeficiency virus SIVmac251-infected rhesus macaques.},
  author={Thorsten Demberg and Egidio Brocca-Cofano and Peng Xiao and David J Venzon and Diego A Vargas-Inchaustegui and Eun Mi Lee and Irene Kalisz and Vaniambadi S. Kalyanaraman and Janet M Dipasquale and Katherine McKinnon and Marjorie Robert-Guroff},
  journal={Journal of virology},
  year={2012},
  volume={86 23},
  pages={
          12591-604
        }
}
Human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) infection causes B-cell dysregulation and the loss of memory B cells in peripheral blood mononuclear cells (PBMC). These effects are not completely reversed by antiretroviral treatment (ART). To further elucidate B-cell changes during chronic SIV infection and treatment, we investigated memory B-cell subpopulations and plasma cells/plasmablasts (PC/PB) in blood, bone marrow, and lymph nodes of rhesus macaques during ART and… CONTINUE READING

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