Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps.

  title={Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps.},
  author={William Joseph Murphy and Denis M. Larkin and Annelie Everts-van der Wind and Guillaume Bourque and Glenn Tesler and Loretta Auvil and Jonathan E. Beever and Bhanu P. Chowdhary and Francis Galibert and Lisa Gatzke and Christophe Hitte and Stacey N Meyers and Denis Milan and Elaine A Ostrander and Greg Pape and Heidi G Parker and T Raudsepp and Margarita B. Rogatcheva and Lawrence B. Schook and Loren C. Skow and Michael Welge and James E. Womack and Stephen J. O'Brien and Pavel A. Pevzner and Harris A. Lewin},
  volume={309 5734},
The genome organizations of eight phylogenetically distinct species from five mammalian orders were compared in order to address fundamental questions relating to mammalian chromosomal evolution. Rates of chromosome evolution within mammalian orders were found to increase since the Cretaceous-Tertiary boundary. Nearly 20% of chromosome breakpoint regions were reused during mammalian evolution; these reuse sites are also enriched for centromeres. Analysis of gene content in and around… CONTINUE READING
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