Dynamics of ligand binding to GPCR: Residence time of melanocortins and its modulation.

Abstract

Ligand binding dynamics and the concept of drug-target residence time are essential factors in the development of novel drugs. Conventional ligand binding assays, which usually collect end-point data, do not provide abundant information regarding the ligand binding kinetics. Therefore, novel methods that allow on-line monitoring of ligand binding processes… (More)
DOI: 10.1016/j.phrs.2016.05.030

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