Dynamics of interictal spikes and high-frequency oscillations during epileptogenesis in temporal lobe epilepsy.

@article{Salami2014DynamicsOI,
  title={Dynamics of interictal spikes and high-frequency oscillations during epileptogenesis in temporal lobe epilepsy.},
  author={Pariya Salami and Maxime L{\'e}vesque and Ruba Benini and Charles Behr and Jean Gotman and Massimo Avoli},
  journal={Neurobiology of disease},
  year={2014},
  volume={67},
  pages={97-106}
}
Mesial temporal lobe epilepsy (MTLE) is characterized in humans and in animal models by a seizure-free latent phase that follows an initial brain insult; this period is presumably associated to plastic changes in temporal lobe excitability and connectivity. Here, we analyzed the occurrence of interictal spikes and high frequency oscillations (HFOs; ripples: 80-200Hz and fast ripples: 250-500Hz) from 48h before to 96h after the first seizure in the rat pilocarpine model of MTLE. Interictal… CONTINUE READING