Dynamics of insulin secretion and the clinical implications for obesity and diabetes.

@article{Seino2011DynamicsOI,
  title={Dynamics of insulin secretion and the clinical implications for obesity and diabetes.},
  author={Susumu Seino and Tadao Shibasaki and Kohtaro Minami},
  journal={The Journal of clinical investigation},
  year={2011},
  volume={121 6},
  pages={2118-25}
}
Insulin secretion is a highly dynamic process regulated by various factors including nutrients, hormones, and neuronal inputs. The dynamics of insulin secretion can be studied at different levels: the single β cell, pancreatic islet, whole pancreas, and the intact organism. Studies have begun to analyze cellular and molecular mechanisms underlying dynamics of insulin secretion. This review focuses on our current understanding of the dynamics of insulin secretion in vitro and in vivo and… CONTINUE READING