Dynamics of immunoglobulins at the feto-maternal interface.

@article{Saji1999DynamicsOI,
  title={Dynamics of immunoglobulins at the feto-maternal interface.},
  author={F. Saji and Y. Samejima and S. Kamiura and M. Koyama},
  journal={Reviews of reproduction},
  year={1999},
  volume={4 2},
  pages={
          81-9
        }
}
Transplacental transport of maternal immunoglobulin G (IgG) to the developing fetus is extremely important in the protection of the newborn from infection. Although the exact mechanisms of the selective and active transfer of IgG across the placental barrier are not fully understood, receptors for the Fc part of IgG (FcgammaRs) in the placenta are believed to play a key role. Several known Fc receptors, FcgammaRI, FcgammaRII, FcgammaRIII and FcRn (neonatal FcR), demonstrate heterogeneous… Expand
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References

SHOWING 1-10 OF 55 REFERENCES
Human placental Fc receptors and the transmission of antibodies from mother to fetus.
TLDR
A consideration of the binding properties and distribution of these proteins suggests that the neonated Fc receptor (FcRn) transports IgG across the syncytiotrophoblast, and possibly the fetal blood vessel endothelium. Expand
Isolation from human placenta of the IgG transporter, FcRn, and localization to the syncytiotrophoblast: implications for maternal-fetal antibody transport.
TLDR
It is suggested that the placental hFcRn heterodimer may transport IgG to the fetus by a mechanism in which maternal IgG is pinocytosed nonspecifically and then carried to fetal tissues by a pH gradient from acidic endosomes to the pH-neutral basolateral surface of the syncytiotrophoblast. Expand
Requirement for a beta 2-microglobulin-associated Fc receptor for acquisition of maternal IgG by fetal and neonatal mice.
TLDR
It is concluded that neonatal mice homozygous for a targeted disruption of the beta 2microglobulin (beta 2m) gene, which encodes one subunit of FcRn, are the only transporter of IgG from mother to young in the mouse, and FcG in sera of beta 2m-/- mice was endogenous and that none was obtained from milk. Expand
A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus
The acquisition of maternal antibodies is critical for immunologic defense of the newborn. In humans, maternal IgG is actively transported across the placenta. The receptor responsible for thisExpand
Membrane-spanning Fc gamma receptor III isoform expressed on human placental trophoblasts.
TLDR
This study has demonstrated by immunohistochemical means that three distinct classes of Fc gamma Rs are expressed in the different cell components of the human placenta, and confirmed that Fc Gamma RIII on PTs is a membrane-spanning molecule, and that it is distinctive from PI anchoring F c gamma R III on granulocytes. Expand
Isolation and characterization of the Fc receptor from the fetal yolk sac of the rat
TLDR
The data suggest that the Fc receptor of the yolk sac is isolated and that this receptor is structurally and functionally related to the F c receptor ofThe neonatal intestine. Expand
Distribution of Fc gamma receptors on trophoblast during human placental development: an immunohistochemical and immunoblotting study.
Expression of Fc gamma receptors on human placental trophoblast was investigated by immunostaining and immunoblotting using a panel of Fc gamma receptor monoclonal antibodies (mAb). Fc gammaExpand
A monoclonal antibody inhibiting human placental Fc gamma-receptor activity.
TLDR
According to the data, the FcR in different anatomical areas in the placenta have a common antigenic determinant, and the monoclonal antibody reacts with the placental Fc R at the binding site for IgG, or with an epitope close to thebinding site. Expand
An Fc receptor structurally related to MHC class I antigens
TLDR
A cDNA encoding the presumptive Fc-binding subunit, p51, has been cloned and its predicted primary structure has three extracellular domains and a transmembrane region which are all homologous to the corresponding domains of class I major histocompatibility complex (MHC) antigens. Expand
Localization of three subtypes of Fc gamma receptors in human placenta by immunohistochemical analysis.
TLDR
The results indicate that the three subtypes of Fc Gamma R in the human placenta may contribute to maintenance of placental functions, because each Fc gamma R molecule displays unique biological functions similar to those on leukocytes. Expand
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