Dynamics of immune cell recruitment during West Nile encephalitis and identification of a new CD19+B220-BST-2+ leukocyte population.

@article{Brhin2008DynamicsOI,
  title={Dynamics of immune cell recruitment during West Nile encephalitis and identification of a new CD19+B220-BST-2+ leukocyte population.},
  author={Anne-Claire Br{\'e}hin and Juliette Mouri{\`e}s and M. P. Frenkiel and Gilles Dadaglio and Philippe Despr{\`e}s and Monique Lafon and Th{\'e}r{\'e}se Couderc},
  journal={Journal of immunology},
  year={2008},
  volume={180 10},
  pages={6760-7}
}
West Nile virus (WNV) is an emerging neurotropic flavivirus. We investigated the dynamics of immune cell recruitment in peripheral tissues and in the CNS during WNV encephalitis in an immunocompetent mouse model. In the periphery, immune cell expansion can successfully limit viremia and lymphoid tissue infection. However, viral clearance in the periphery is too late to prevent viral invasion of the CNS. In the CNS, innate immune cells, including microglia/macrophages, NK cells, and plasmacytoid… CONTINUE READING

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