Dynamics of human replication factors in the elongation phase of DNA replication

@inproceedings{Masuda2007DynamicsOH,
  title={Dynamics of human replication factors in the elongation phase of DNA replication},
  author={Yuji Masuda and Miki Suzuki and Jinlian Piao and Yongqing Gu and Toshiki Tsurimoto and Kenji Kamiya},
  booktitle={Nucleic acids research},
  year={2007}
}
In eukaryotic cells, DNA replication is carried out by coordinated actions of many proteins, including DNA polymerase delta (pol delta), replication factor C (RFC), proliferating cell nuclear antigen (PCNA) and replication protein A. Here we describe dynamic properties of these proteins in the elongation step on a single-stranded M13 template, providing evidence that pol delta has a distributive nature over the 7 kb of the M13 template, repeating a frequent dissociation-association cycle at… CONTINUE READING
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