Dynamics of human erythroblast enucleation.

  title={Dynamics of human erythroblast enucleation.},
  author={Miwa Hebiguchi and Makoto Hirokawa and Yong-mei Guo and Kunie Saito and Hideki Wakui and Atsushi Komatsuda and Naohito Fujishima and Naoto Takahashi and Tsutomu Takahashi and Takehiko Sasaki and Wataru Nunomura and Yuichi Takakuwa and Kenichi Sawada},
  journal={International journal of hematology},
  volume={88 5},
How human erythroblasts enucleate remains obscure, and some investigators suspect the effect of mechanical forces on enucleation in vitro. We determined the dynamics of the enucleation process of highly purified human erythroblasts and whether enucleation can occur without external mechanical forces. Highly purified human CD34(+) cells were cultured in liquid phase with interleukin-3, stem cell factor and erythropoietin (EPO) for 7 days and the generated erythroblasts were replaced in the same… CONTINUE READING


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