Dynamics of histone lysine methylation: structures of methyl writers and erasers.

  title={Dynamics of histone lysine methylation: structures of methyl writers and erasers.},
  author={Anup K Upadhyay and Xiaodong Cheng},
  journal={Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques},
In Eukarya, the packaging of DNA into chromatin provides a barrier that allows for regulation of access to the genome. Chromatin is refractory to processes acting on DNA. ATP-dependent chromatin remodeling machines and histone-modifying complexes can overcome this barrier (or strengthen it in silencing processes). Both components of chromatin (DNA and histones) are subject to postsynthetic covalent modifications, including methylation of lysines (the focus of this chapter). These lysine marks… CONTINUE READING

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