Dynamics of gene silencing by RNA interference.

  title={Dynamics of gene silencing by RNA interference.},
  author={R. Michael Raab and Gregory Stephanopoulos},
  journal={Biotechnology and bioengineering},
  volume={88 1},
The large number of candidate genes identified by modern high-throughput technologies require efficient methods for generating knockout phenotypes or gene silencing in order to study gene function. RNA interference (RNAi) is an efficient method that can be used for this purpose. Effective gene silencing by RNAi depends on a number of important parameters, including the dynamics of gene expression and the RNA dose. Using mouse hepatoma cells, we detail some of the principal characteristics of… CONTINUE READING

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