Dynamics of gene regulatory networks with cell division cycle.

  title={Dynamics of gene regulatory networks with cell division cycle.},
  author={Luonan Chen and Ruiqi Wang and Tetsuya J. Kobayashi and Kazuyuki Aihara},
  journal={Physical review. E, Statistical, nonlinear, and soft matter physics},
  volume={70 1 Pt 1},
This paper focuses on modeling and analyzing the nonlinear dynamics of gene regulatory networks with the consideration of a cell division cycle with duplication process of DNA, in particular for switches and oscillators of synthetic networks. We derive two models that may correspond to the eukaryotic and prokaryotic cells, respectively. A biologically plausible three-gene model ( lac, tetR, and cI ) and a repressilator as switch and oscillator examples are used to illustrate our theoretical… CONTINUE READING

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