Dynamics of gene expression and the regulatory inference problem

  title={Dynamics of gene expression and the regulatory inference problem},
  author={Johannes Berg},
From the response to external stimuli to cell division and death, the dynamics of living cells is based on the expression of specific genes at specific times. The decision when to express a gene is implemented by the binding and unbinding of transcription factor molecules to regulatory DNA. Here, we construct stochastic models of gene expression dynamics and test them on experimental time series data of messenger-RNA concentrations. The models are used to infer biophysical parameters of gene… 

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