Dynamics of forced nucleosome unraveling and role of nonuniform histone-DNA interactions.

Abstract

A coarse-grained model of the nucleosome is introduced to investigate the dynamics of force-induced unwrapping of DNA from histone octamers. In this model, the DNA is treated as a charged, discrete worm-like chain, and the octamer is treated as a rigid cylinder carrying a positively charged superhelical groove that accommodates 1.7 turns of DNA. The groove… (More)

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Cite this paper

@article{Dobrovolskaia2012DynamicsOF, title={Dynamics of forced nucleosome unraveling and role of nonuniform histone-DNA interactions.}, author={Irina V. Dobrovolskaia and Gaurav Arya}, journal={Biophysical journal}, year={2012}, volume={103 5}, pages={989-98} }