Dynamics of calcium sparks and calcium leak in the heart.

  title={Dynamics of calcium sparks and calcium leak in the heart.},
  author={George S. B. Williams and Aristide C. Chikando and Hoang-Trong Minh Tuan and Eric A. Sobie and W. Jonathan Lederer and M. Saleet Jafri},
  journal={Biophysical journal},
  volume={101 6},
We present what we believe to be a new mathematical model of Ca(2+) leak from the sarcoplasmic reticulum (SR) in the heart. To our knowledge, it is the first to incorporate a realistic number of Ca(2+)-release units, each containing a cluster of stochastically gating Ca(2+) channels (RyRs), whose biophysical properties (e.g., Ca(2+) sensitivity and allosteric interactions) are informed by the latest molecular investigations. This realistic model allows for the detailed characterization of RyR… CONTINUE READING


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Optical singlechannel resolution imaging of the ryanodine receptor distribution in rat cardiac myocytes

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