Dynamics of blood flow and oxygenation changes during brain activation: The balloon model

@article{Buxton1998DynamicsOB,
  title={Dynamics of blood flow and oxygenation changes during brain activation: The balloon model},
  author={R. Buxton and E. Wong and L. Frank},
  journal={Magnetic Resonance in Medicine},
  year={1998},
  volume={39}
}
A biomechanical model is presented for the dynamic changes in deoxyhemoglobin content during brain activation. The model incorporates the conflicting effects of dynamic changes in both blood oxygenation and blood volume. Calculations based on the model show pronounced transients in the deoxyhemoglobin content and the blood oxygenation level dependent (BOLD) signal measured with functional MRI, including initial dips and overshoots and a prolonged post‐stimulus undershoot of the BOLD signal… Expand
1,608 Citations
The roles of changes in deoxyhemoglobin concentration and regional cerebral blood volume in the fMRI BOLD signal
  • 121
  • Highly Influenced
Spatiotemporal BOLD dynamics from a poroelastic hemodynamic model.
  • 43
The effects of capillary transit time heterogeneity on the BOLD signal
  • 5
  • Highly Influenced
Computational modeling of the transient hemodynamic response in cerebral cortex
  • J. Kim, R. Khan, D. Ress
  • Chemistry, Medicine
  • 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • 2012
Modeling the hemodynamic response to brain activation
  • 1,017
  • PDF
A Model of the Dynamic Relationship between Blood Flow and Volume Changes during Brain Activation
  • Y. Kong, Y. Zheng, +4 authors J. Mayhew
  • Psychology, Medicine
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2004
  • 67
  • Highly Influenced
Vascular dynamics and BOLD fMRI: CBF level effects and analysis considerations
  • 57
  • Highly Influenced
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 46 REFERENCES
A Model for the Coupling between Cerebral Blood Flow and Oxygen Metabolism during Neural Stimulation
  • R. Buxton, L. Frank
  • Chemistry, Medicine
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 1997
  • 755
  • PDF
Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation
  • 520
Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.
  • 3,931
  • PDF
Tracer oxygen distribution is barrier-limited in the cerebral microcirculation.
  • 56
Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects.
  • P. Fox, M. Raichle
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1986
  • 1,943
  • PDF
...
1
2
3
4
5
...