Dynamics of bivalent chromatin domains upon drug induced reactivation and resilencing in cancer cells.

@article{Mayor2011DynamicsOB,
  title={Dynamics of bivalent chromatin domains upon drug induced reactivation and resilencing in cancer cells.},
  author={Regina Mayor and Mar Mu{\~n}oz and Marcel W. Coolen and Joaquin Custodio and Manel Esteller and Susan J. Clark and Miguel A. Peinado},
  journal={Epigenetics},
  year={2011},
  volume={6 9},
  pages={1138-48}
}
Epigenetic deregulation revealed by altered profiles of DNA methylation and histone modifications is a frequent event in cancer cells and results in abnormal patterns of gene expression. Cancer silenced genes constitute prime therapeutic targets and considerable progress has been made in the epigenetic characterization of the chromatin scenarios associated… CONTINUE READING