Dynamics of bidirectional transport of Arc mRNA in neuronal dendrites.

@article{Dynes2007DynamicsOB,
  title={Dynamics of bidirectional transport of Arc mRNA in neuronal dendrites.},
  author={Joseph L. Dynes and Oswald Steward},
  journal={The Journal of comparative neurology},
  year={2007},
  volume={500 3},
  pages={
          433-47
        }
}
The mRNA for Arc (activity-regulated cytoskeletal protein) is delivered into dendrites and localizes selectively at active synapses. Here we use a green fluorescent protein-based labeling system and confocal microscopy to define the transport kinetics of exogenously expressed mRNA from chimaeric Arc constructs (Arc/MS2 mRNA) in the dendrites of living rat neurons in culture. Arc/MS2 mRNA assembles into particles that move independently, bidirectionally, and intermittently in a fashion… CONTINUE READING
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