Dynamics of a novel centromeric histone variant CenH3 reveals the evolutionary ancestral timing of centromere biogenesis

@inproceedings{Dubin2010DynamicsOA,
  title={Dynamics of a novel centromeric histone variant CenH3 reveals the evolutionary ancestral timing of centromere biogenesis},
  author={Manu Dubin and Joerg Fuchs and Ralph O Gr{\"a}f and Ingo Schubert and Wolfgang Nellen},
  booktitle={Nucleic acids research},
  year={2010}
}
The centromeric histone H3 variant (CenH3) serves to target the kinetochore to the centromeres and thus ensures correct chromosome segregation during mitosis and meiosis. The Dictyostelium H3-like variant H3v1 was identified as the CenH3 ortholog. Dictyostelium CenH3 has an extended N-terminal domain with no similarity to any other known proteins and a histone fold domain at its C-terminus. Within the histone fold, α-helix 2 (α2) and an extended loop 1 (L1) have been shown to be required for… CONTINUE READING
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